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Because WT neurons fired at stable locations, they fired one after another with a stable, position-locked sequence in every lap of a trajectory.
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To compare the spatial response in a cell's spiking activity with the chance level, we shuffled the spiking activity of the cell during a lap on a trajectory by random, circular shifting (Henriksen et al., 2010; Igarashi et al., 2014).
Given a pair of neurons, CC was computed for each lap on a trajectory.
Given any two laps of a trajectory, suppose the cell's firing rates at the i-th bin were x i and y i.
Given any two laps of a trajectory, suppose the neuron's firing rates at the i-th bin are x i and y i.
Trajectory SI was given by Equation [1] with x i and t i computed using the neuron's spikes and the animal's occupancy time during all laps of a trajectory.
9) In the subsection "Random shuffling and spatial modulation index (SMI)", I did not understand what the authors meant by "a copy" in the following passage: "A copy of random spiking activity for the cell was the random spike trains for all the laps on a trajectory".
To compare with the location-specificity arising randomly from chance, we randomly shuffled the cell's spiking activity by circularly shifting the spikes within each lap of the trajectory with a random time interval (Henriksen et al., 2010; Igarashi et al., 2014).
For each panel, the top displays the spike raster of a cell within every lap of running on a trajectory, which is linearized and plotted as the x-axis.
SI was computed for each neuron active on each trajectory at two levels, a lap SI to measure the location-specificity at individual lap level and a trajectory SI to measure the overall location-specificity across all laps based on its averaged rate curve.
The location-specific increase in firing activity of V1 cells was apparently stable during each lap of the trajectory.
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Justyna Jupowicz-Kozak
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