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The latter is consistent with the heterogeneity typically observed in clinically probable Alzheimer's disease in contrast to the more stereotyped patterns of language abnormality that are associated with the syndromes of primary progressive aphasia (Gorno-Tempini et al., 2011).
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Functionally there is a growing body of literature suggesting sensory perception abnormalities that have parallels in both conditions and that may be upstream of language abnormalities.
Patients, in whom neural degeneration begins on the left side, often present to the clinicians at an early stage of the disease due to the presence of language abnormalities, but maintain their emotion processing abilities, being preserved the right anterior temporal lobe.
Specific language abnormalities may be associated with pathology in Wernicke's area or Broca's area of the brain.
The above mentioned results suggest that language development may be strongly affected by social factors and language abnormalities are the first observed deficit observed in more than half the families of children with ASD [23], [24].
FTLD is a heterogeneous group of neurodegenerative disorders that is characterized clinically by either behavioural changes, such as in personality and social conduct; and/or language abnormalities, such as aphasia [4].
Language abnormalities in non-demented ALS also occur but less frequently.
The presence of speech and language abnormalities, macrocephaly and PDD in this child coincides with previously reported core phenotypes of chromosome 16p deletions.
FTLD is characterised by declines in social function, interpersonal conduct, emotional blunting, speech and language abnormalities and loss of insight [ 4].
Based on these results we assume that the self-perception of language abnormalities could be an important aspect in the assessment of AS.
As mentioned above, care has been taken to strictly follow the NICE-guidelines in establishing a diagnosis, and pragmatic language abnormalities are not of high relevance in this process.
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