Exact(9)
A formal landmark survival analysis was performed with the landmark time point chosen as ICU discharge.
Such RCTs should preferably assess impact on 90-day landmark survival, acute cellular metabolism and long-term functional outcome.
The landmark survival analysis (with the landmark set at 3 months after date of initiation of bevacizumab-containing therapy) was performed.
Other alternatives to median OS are endpoints relating to landmark survival rates, for example at 2, 3, and 5 years after the start of therapy or whichever duration is appropriate to the type of therapy.
Data on demographics, HSCT course, chronic graft-versus-host disease (cGVHD), smoking and alcohol consumption, oral lesion characteristics, mode of therapy and clinical outcome were recorded; landmark survival was calculated.
Although long-term trial follow-up is required, landmark survival at up to 5 years after treatment has been reported with some agents for some solid tumors and hematologic malignancies [ 7, 8, 30, 31].
Similar(51)
However, exploratory landmark analysis of survival of patients who received >10 vaccines showed, after adjustment for survival bias, a separation of both arms in Kaplan Meier plots in favour of the Vitespen-treated patients for all patients and statistical significance for combined data from M1a + M1b patients (P = 0.03; HR = 0.45; 95% CI, 0.21 0.96).
To clarify the importance of diabetes as a prognostic factor we performed landmark analysis illustrating survival in diabetics and non diabetics adjusted for age, sex and wall motion index in 2 year intervals after the infarction.
Cox proportional hazard models were used to explore the possible relationship of low-dose intensity (defined using thresholds of 0.7, 0.8, and 0.9) and treatment modifications during the landmark periods to survival.
Bellomo and colleagues avoided this problem by using landmark 90-day-survival independent of ICU or hospital discharge status [ 1].
Therefore within this study, we assessed the fraction of TS at first assessment on overall survival, incorporating landmark analyses.
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