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Using restriction genome landmark scanning (RLGS), Smiraglia and colleagues concluded, however, that the three colon cancer cell lines in their study were in fact the most similar to their primary counterparts.
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Global methylation was analyzed using restriction landmark genomic scanning (RLGS) as previously described [ 17].
Restriction landmark genomic scanning (RLGS) was also used to assess the methylation in human malignancies.
In this study, we identify TCF4 as a hypermethylated gene in gastric cancers using restriction landmark genomic scanning (RLGS) analysis.
Restriction Landmark Genomic Scanning (RLGS) detected differences in DNA methylation between tissues more than 15 years ago [ 16- 19].
Another approach based on the restriction landmark genomic scanning (RLGS) allowed the identification of genes encoding for NOL4 and LHFPL4 as methylated in cervical cancer [ 71].
The first genome-wide study of DNA methylation in TGCT used the technique of restriction landmark genome scanning (Smiraglia et al, 2002).
To elucidate the molecular basis of the specialization of cortical architectures, we searched for genes differentially expressed among neocortical areas of Old World monkeys by restriction landmark cDNA scanning.
We first used the restriction landmark genome scanning (RLGS) technique to identify hypermethylated loci in L1210 compared to the control DBA2.
Restriction landmark genomic scanning (RLGS) has been used to study aberrant CpG island methylation in cancer for more than ten years.
Performing restriction landmark genomic scanning (RLGS) they identified 34 differentially methylated CpG islands, which revealed neural specific CpG island hypermethylation compared with mesoderm- or endoderm-derived tissues.
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