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Landmark analysis was performed 12 and 24 months after percutaneous coronary intervention, and patients were stratified according to continued use of DAPT or not.
The landmark analysis was performed for statistical analyses.
Therefore, in an attempt to address this important issue, a landmark analysis was also performed.
To additionally consider time-dependency a landmark analysis was performed at the time point 0, Day 7 and Day 14 based on the Cox-Regression.
A landmark analysis was performed to examine the association among PFS, OS and rash development by C1D8 (after 21 days of cetuximab therapy as in Gatzemeier, et al).
When a landmark analysis was performed at 6 months, the median OS for patients in group 2 compared to group 3 was 67 vs 51 months (P=0.175).
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Using the National Heart ,Lung, and Blood Institute Dynamic Registry, patients enrolled in the last 2 waves after index percutaneous coronary intervention with DES and who were event free at the time of landmark analysis were included.
The hazard ratio (HR) of patients who achieved progression-free to those who progressed at each landmark analysis is described in Figure 2.
Sensitivity analyses for the extended versus 12 month regimen comparison after inclusion of the PRODIGY landmark analysis are in web figures 12-18.
To avoid this problem, a landmark analysis is sometimes employed, in which the study is limited to patients who survive for at least certain specific time period after the initiation of treatment, with neutropenia during that period considered as a baseline feature (Di Maio et al, 2005).
A formal landmark survival analysis was performed with the landmark time point chosen as ICU discharge.
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