Consistent with the six-layer model originally proposed by Brodmann [1], the lamina expressions of several genes were conserved across areas in monkey and mouse neocortices.
These observations indicate heterogeneous lamina expression patterns of the "layer-specific" genes at the cellular level.
The characteristic area and lamina expression patterns of PNMA5 mRNA and the sequence divergence in mammals suggest its involvement in functions particular to association areas in the neocortex of primates.
Lamina propria expression of bak has been shown to gradually increase over 20 wk of infection by H. pylori in mice (4, 11), and expression of bcl-2 family members is also altered in hypergastrinaemic mice, which may be a significant factor responsible for their increased susceptibility to H. felis-induced gastric carcinogenesis (7, 38).
In earlier studies, we reported unique area- and lamina-associated expression of occ1 and Rbp and their complementary patterns in the monkey neocortex (Yamamori and Rockland 2006).
Autoradiographs revealed significant and lamina-specific expression of α1, α2 and β1/2 noradrenergic receptor subtypes in particular in the DG molecular layer and the stratum lacunosum moleculare (Fig. 6a), indicating a substantial noradrenergic innervation of the layers harbouring diffuse pE-Aβ deposits.
To establish the intranuclear localization of the fluorescent viral particles, we have exploited at least two methods for nuclear visualization: nuclear lamina immunostaining and expression of histones H2B fused to the Enhanced Yellow Fluorescent Protein (H2B-EYFP).
Indeed, high resolution maps of genome-nuclear lamina interactions reveal that expression of pluripotent genes Oct4, Nanog and several others depends on their spatial distribution relative to nuclear lamina (Peric-Hupkes et al., 2010).
However, lamina propria mononuclear cells expression of TLR4 and MD2 was similar in uninfected and infected biopsies.
The stresses that arterioles undergo, that normally do not exhibit contacts between endothelial- and SMCs because of the interposed internal elastic lamina, may have triggered the expression of connexin Cx37 in SMCs, which was formerly only weakly expressed in endothelium [ 18, 19].
