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The time frame and organisational rules of procedure laid down in the study protocol will be continually evaluated in order to ensure that they are adhered to.
Scrutiny of heat resistance values chosen according to the stipulations laid down in the study, however, indicated that value differences probably caused by differences in experimental conditions were, in most cases, small or moderate.
It is considered good clinical practice that the strategy and methodology for data analysis of a particular trial are laid down in the study protocol and analysis details are further described in a corresponding statistical analysis plan, which is prepared in advance of trial commencement (or prior to data base lock/unblinding).
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Roger Geffen, of Cycling UK, said it was not too late for HS2 to take heed of the design principles laid down in the feasibility study.
The study conformed with guidelines laid down in the Declaration of Helsinki II and was approved by the Copenhagen and Frederiksberg Ethics Committee, Denmark.
The study will be conducted in accordance with the ethical principles as laid down in the declaration of Helsinki.
The study was in compliance with the 'Ethical Principles for Medical Research Involving Human Subjects' as laid down in the Helsinki Declaration [ 16].
The studies were performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
The study was approved by institutional review board (LEC-06-15-070) and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki.
This study was approved by the institutional review board and has been written according to the ethical standards as laid down in the 1964 Declaration of Helsinki.
Details on methods and design are laid down in the original study protocol, which can be requested from the corresponding author.
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