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Therefore, based on the random distribution model, the expected number of L1-embedded NANOG-binding sites located within LADs is estimated at 72, which is significantly less than the observed number of 104 binding events located within LADs (fig. 1).
We estimated LAD-level deprivation using the 2004 Index of Multiple Deprivation (IMD) in England, which estimated domains of deprivation using measures predominantly collected close to the time of our case ascertainment periods (see table 1).
We estimated population density by dividing each LAD's usual resident population by its area (in hectares), using ArcGIS V.9.3 software.
Parasternal long axis measurements of aorta and left atrial diameter (LAD), at the aortic valve level during systole period, were estimated (LA/Aorta).
The whole and three regional (left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) territory) MBF values were estimated.
R-Lasso and ℓ 1-LAD are slightly more robust than ℓ 1-LS because the true support is correctly estimated although some components outside the true support also have strong amplitude.
Let β ^ i be the LAD-aFL estimate using the above SIC strategy and μ ^ i (= β ^ i − β ^ i − 1 ) be the estimated jump at marker i.
We estimated the population at-risk of East Anglia using 2009 mid-year census estimates published by the Office for National Statistics (ONS) at the LAD level, by age group, sex and ethnicity.
We also derived EIS-level (4) and LAD-level (5) RMSE scores to estimate prediction error from each model in our validation sample.
Estimates for FADs and LADs (last appearance datums) are averages of the oldest and youngest ages for the smallest reported stratigraphic interval (Table 2; Additional file 2: Table S2).
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