Sentence examples similar to laden with difficulties from inspiring English sources
While human cyclin A constructs have been extensively characterized in complex with cyclin dependent kinase 2 (CDK2), efforts to express the monomeric human cyclin A2 in Escherichia coli in a stable form, without the kinase subunit, have been laden with technical difficulties, including solubility, yield and purity.
Down the street of the village, across the south meadows, up Bars' long hill and over the plain, they took their way, marching but slowly, for the heavy laden teams moved with difficulty over the rough road.
Clubbing – as I've previously documented – can be fraught with difficulties and the majority of these come when you come laden with expectation.
If they obliterated Osama bin Laden with a missile, they would have difficulty proving he was dead.
But the hell with difficulties.
Having worked on both sides of the Mason-Dixon line, each man is also keenly aware of the difficulty of achieving fairness and avoiding advocacy in an emotionally charged setting laden with stereotypes.
We killed Bin Laden with a bullet.
The case was laden with inconsistencies.
Then, laden with presents, weeping, she departs.
The house is laden with icicles.
