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Lactate may increase to attenuate the electrical activity of excessively active neurons as observed in experimental models [22, 24, 25] and in healthy humans during sustained visual stimulation [26].
The level of metabolites such as lactate may increase at postmortem.
Although cerebral lactate may increase at high altitude [ 28, 29], lactate did not dramatically elevate after ICH at high altitude compared to low altitude in our study.
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Nevertheless, in septic states, lactate concentration may increase through other mechanisms unrelated to tissue oxygen debt [3, 4].
The lactate concentration may increase transiently in patients treated with epinephrine.
In their present study, Michaeli and colleagues clearly show that lactate elevation may increase without any oxygen delivery compromise.
Increased liver blood flow (LBF) resulting from elevated feed intake in lactating dairy cows may increase steroid metabolism.
In addition, it is worth noting that our study was potentially limited by having to add lactate measurements to the composite APACHE II score, rather than its component parts, and that a completely re-derived risk prediction equation that includes one or more index of lactate may further increase the predictive ability over that shown in this study.
Although frequently used to diagnose inadequate tissue oxygenation, other processes not related to tissue oxygenation may increase lactate levels.
Fully oxygenated tissues may increase lactate production due to an enhanced glycolytic rate.
Gelatine, which is often described as safe and harmless, developed acidosis, which may be due to reduced Hb following anaerobic metabolism, and additionally Gel group showed severe hypoglycaemia which may increase lactate and aggravated metabolic acidosis.
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