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One major limitation of residue-specific incorporation of unnatural amino acids into proteins via methionine biosynthesis pathway is that this metabolic approach lacks target specificity as the methionine surrogates are incorporated into other methionine-containing proteins.
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Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies.
We now realize that there are at least 5 intrinsic subtypes within breast cancer, at least one of which the basal-like currently lacks targeted therapies and is the most pressing therapeutic challenge for the next decade.
This subgroup of patients currently lacks targeted therapeutic options.
TNBC, as a whole, has a poor prognosis and unlike ER+ and HER2+ tumours currently lacks targeted therapies, leaving systemic chemotherapy as the only adjuvant treatment option.
The basal-like breast cancer subtype represents one of the most aggressive and lethal types of breast cancer, and due to poor mechanistic understanding, it lacks targeted therapy.
Gazit et al. (2005) found diminished response when an area searched repeatedly was lacking target scent.
Despite their success, radiopharmaceuticals lack target specificity, as evidenced by dose-limiting side effects such as bone marrow suppression.
These data demonstrate the advantage of a genetic approach to dissect complex signaling pathways over the use of chemical inhibitors that frequently lack target specificity.
In contrast to other breast cancer subtypes, these patients currently lack targeted treatment alternatives and would therefore benefit from the introduction of new, molecularly targeted drugs.
But he will never lack targets for his idealistic ire.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com