Although carnosol possesses the stronger inhibitory activity in vitro, in vivo it seems to lack substantial effects.
Moreover, reports that link NF-κB activity to the repression of anti-apoptotic genes lack substantial evidence examining the overall effects of NF-κB inhibition on the cytotoxicity of doxorubicin, which is an important question in regards to future clinical applications [11], [12].
Most organisms lack substantial hard parts and rarely fossilize.
Graduate and professional students lack substantial political influence.
The depression was broad and lacked substantial thunderstorm activity.
The lack of a substantial effect of SR-B1 deficiency was surprising, however, considering the elevated serum cholesterol levels in SR-B1−/− mice (Fig. 6A and C).
This model suggests that in a population barely capable of exploiting an opportunity, which lacks better competitors, mutations of substantial effect, would have a meaningful chance of being favorable in the opportunity-rich Cambrian world, even though in today's competitive world they would be disasters.
In contrast, cichoric acid and vehicle treatment produced no clustering differences, which suggests the lack of a multi-domain or substantial effect of cichoric acid on most expressed genes in iDCs.
Bone marrow that lacks miR-155 significantly promotes lung metastasis but does not have a substantial effect on primary tumor growth.
The finding that anti-4-1BB was indeed effective when transferred cells lack but host cells express 4-1BB, also explains the substantial effect of anti-4-1BB in tumor control even in the absence of transferred T cells (Figure 4A).
In contrast to the lack of an effect of phosphorylation, phenylalanine has a substantial effect on the sedimentation behavior.
