Most Chinese guideline users rely on recommendations developed by professional groups that lack demonstration of transparency (including conflict of interest management and evidence synthesis) and quality.
The sweat test is not a perfect reference standard, but is better than mutation-based alternatives that lack demonstration of functional defects.
DOI: http://dx.doi.org/10.7554/eLife.10027.012 Many previous in vitro observations of FG-TF interactions lacked demonstration of reversibility and showed strong affinities (Frey and Görlich, 2009; Tetenbaum-Novatt et al., 2012; Labokha et al., 2013; Kapinos et al., 2014), incompatible with the rapid transport rates observed in vivo.
The publication also lacks the demonstration of target expression.
One of the main criticisms of lung cancer screening is the lack of demonstration of a reduction in mortality.
Assessment of this difference is hampered by the lack of demonstration of uptake of C-labeled ATP into the empty vesicles in the former work.
In neither patient population does the strength of existing findings, coupled with a lack of demonstration of a possible mechanism of effect justify the commitment of resources to large-scale studies [ 39].
The difficulty in ascribing true biochemical essentiality to silicon probably emanates from a lack of demonstration of any silicon-requiring biochemistry and specifically Si-C, Si-O-C, Si-N, et c. bonds in any form of extant life [ 2].
In our study, the lack of demonstration of a statistically significant difference between omeprazole and rabeprazole for the main endpoint, i.e. 24-h percent time pH > 3, may be due to a second espece risk.
All together, these characters might justify separate species designation of NSH adopting a Phylogenetic Species Concept, but the lack of demonstration of the genetic basis of these characters and absence of analysis of phenotype-environment associations would inevitably cast doubt on this classification.
[Editors' note: the author responses to the first round of peer review follow.] 1) The most important issue with this manuscript has to do with incomplete or unclear quantitation of data, use of statistical tests that are not described at all, and lack of demonstration of reproducibility.
