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This suggests the lacking virulence of the BT 1A strains.
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Extensive trials of M. microti as a vaccine suggest that it lacks virulence for humans with normal immunity.
Integrating multi-omic datasets from Salmonella mutants lacking virulence regulators not only identified novel virulence factors but also defined a new class of translocated effectors involved in pathogenesis.
Strains lacking the aspartic proteases Yps7 and Yps10 were also decreased in virulence in the fly model, an observation reminiscent of our recent finding that a yps1-11Δ strain lacks virulence in the Drosophila model (Quintin et al., 2013).
Further evidence for a role in colonization may be the fact that these isolates do not carry the PVL genes, suggesting that they lack the virulence of other MRSA epidemic clones.
The lack of virulence of this bacterium could also explain a relatively low mortality.
The fact that no cases of severe disease were recognized in the large numbers of patients seen during the 1974 WNV epidemic in South Africa could indicate that isolates of lineage 2 lack virulence, but little clinical awareness of the pathogenic potential of arboviruses in general may also have played a role.
Both plasmids are required for virulence; lacking 1 of the plasmids attenuates the microorganism.
BS176 is a variant of M90T lacking the virulence plasmid [32].
In order to weed out virulence-irrelevant responses, expression profiles of isogenic avirulent strains lacking essential virulence regulators [ 21, 22] were compared in parallel.
However, naturally occurring isolates have been found lacking either virulence plasmid, and a number of laboratory strains have been plasmid cured, as well.
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