Previously, structure-based drug design was used to develop substituted diphenyl ethers with potency against the Mycobacterium tuberculosis (Mtb) enoyl-ACP reductase (InhA), however, the highly lipophilic centroid compound, SB-PT004, lacked sufficient efficacy in the acute murine Mtb infection model.
Patient-derived exosomes have been employed as a novel cancer immunotherapy in several clinical trials, but at this point lack sufficient efficacy.
We are lacking sufficient clinical data on the efficacy of combination antifungal therapy.
Even blocking reagents such as soluble FcγRs may lack sufficient therapeutic efficacy because they will prevent IgG-containing immune complexes from binding to activating but also inhibitory FcγRs.
On the other hand, we are lacking sufficient data regarding intraocular penetration of caspofungin and its efficacy in ophthalmic infections.
However, in an era of 'evidence-based medicine', the efficacy of the MET and utility of the RRS have been criticised for lacking sufficient high-quality evidence in the form of randomised controlled trials.
Many of them found discharge letters lacking sufficient information.
Perifosine, an Akt inhibitor, can be safely administered, but it lacks sufficient anti-cancer efficacy in cancer patients.
Clinical studies of therapies for chronic pain typically lack sufficient numbers of older patients to evaluate the safety and efficacy of analgesics in this population.
This subgroup of patients was relatively small, and the study lacked sufficient statistical power to draw any meaningful conclusions regarding the efficacy of A. paniculata in this patient population.
Currently, AL and ASAQ retain high clinical efficacy with few recrudescent infections, and individual studies generally lack sufficient statistical power to assess the association between parasite genotypes and outcomes of clinical treatment.
