Exact(32)
Even when lacking sequence alignments, numerous large acquired gene clusters in sequenced genomes can be associated with each other individually via substantial compositional similarities.
These findings allowed the design of a completely artificial protein, lacking sequence homology with native tetherin, that nevertheless mimicked its antiviral activity.
Other proteins with predicted 'arrestin-like' structural domains but lacking sequence homology have been indicated to function like β-arrestin in receptor regulation.
Shared common activities between these assays can enhance our understanding of the pathways of interactions especially when it is difficult to infer an explicit relationship between the biological targets (e.g. lacking protein protein interaction or lacking sequence similarity).
The nucleotide sequences of the human SHMT2 and mouse shmt2 intron 1/exon 2 boundaries were BLASTED against both the human and mouse EST databases to identify alternative SHMT2 and Shmt2 transcripts lacking sequence encoded by exon 1 but containing intron 1 sequence within the 5'-untranslated 5'-untranslated
Further, highly expressed and fast evolving functional miRNA that are lacking sequence conservation might still be missed.
Similar(28)
The major overlap of the two lists validated our previous research designed for gene discovery and transcript profiling in organisms lacking sequenced genomes.
Transgene rescue experiments showed that a dCTCF protein lacking sequences critical for CP190 interactions was almost as effective as wild type in rescuing the phenotypic effects of a dCTCF null allele.
We demonstrated a strategy for selecting and utilizing near neighbor organism genome sequences that enabled proteomics characterization of unsequenced environmental isolates lacking sequenced genomes.
Lipids are a class of their own in this respect, being essentially monomeric, but share the attribute of lacking sequence-related combinatorics.
This suggests the method can be applied to many domestic and wildlife species lacking sequenced genomes.
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