If you lack preliminary data to prove that your system or model is valid, then you need to generate the data before you resubmit.
While reliable cost-effectiveness data are lacking, preliminary costing exercises from other countries such as Rwanda suggest that coverage of rural populations using community health workers can be achieved for as little as $3 USD per person per year (M. Rich, personal communication, January 25 , 2011 or 7% of total health expenditures [ 61].
The NRC report inspired another of the initiatives: a new grant competition at the National Institute of Environmental Health Sciences (NIEHS) for investigators lacking enough preliminary data for a full-fledged NIH proposal.
Although studies focusing specifically on psychiatric complications of DAAs are lacking, this preliminary data suggests that DAAs confer a minimal risk of additional neuropsychiatric side effects.
For instance, information on the biological significance of the E7 expression in these tumours is lacking, but preliminary data indicate that the presence of E7 can improve cell growth rate.
However, a more detailed structure-activity relationship study to reveal the contribution of specific structural elements, for instance length of the aliphatic side chain and position of the heterocyclic nitrogen, is lacking and preliminary data indicated that substitution of bromine by other halogens might lead to more active compounds [ 54].
Unfortunately, many GWAS findings lack follow-up owing to the sheer number of loci and genes identified or lack of preliminary data to warrant an in-depth investigation of individual gene candidates.
In Wisconsin — where 55percentt of African American men and 49percentt of African American women lack state identification — preliminary data indicate that the photo ID law could be racially discriminatory.
When I first started this work, my grant renewal application did not get a fundable score because of the risky nature of the project and the lack of convincing preliminary data.
However, because of its lack of toxicity and preliminary data showing some activity in other types of cancer, combination of IM862 with other drugs such as chemotherapy or biologic agents could be worth considering, especially if a biological effect such as the decrease of VEGF levels could be confirmed.
EAGER awards should be reserved for situations, he says, in which "a PI [principal investigator] has a brilliant new way to tackle a problem, but lacks the resources to collect the preliminary data needed to show that it's possible".
