A more important issue, by contrast, is the site's current lack of permeability.
However the lack of permeability greatly limited it from further clinical application.
Additionally, a lack of permeability in institutions' boundaries (be it from one organization to the next, from one occupation to another, from theory to praxis, from university to industry, or from family to work) places heavy biographic risks on every single scientist.
The 20-fold difference in internal and external concentrations is indicative of the lack of permeability of the C. elegans cuticle.
This is likely to be partially due to lack of cellular permeation (a hypothesis supported in part by lack of permeability in Caco-2 cells).
The latter result is most encouraging as the lack of permeability across the outer membrane of A. baumannii is a significant challenge in medicinal chemistry.
3 In most cases, efflux or lack of permeability across the bacterial cell wall has been suspected to be a principal factor responsible for this phenomenon.
1, 2 The lack of efficacy of potent enzyme inhibitors has been primarily attributed to the efflux of the molecule or lack of permeability across the bacterial cell wall.
The pharmacological manipulations, which can prevent free [Ca2+]i movements through the disruption of internal stores as well as acting on the plasma membrane, together with the lack of permeability to ethidium bromide, parallel to the [Ca2+]i increase, strongly supports the notion that the formation of a pore is not the first cellular effect induced by leukotoxins in neurones.
Other studies of gastric (186) or arterial (187) smooth muscle detected caffeine-stimulated nonselective cation channels in the PM, but their insensitivity to ryanodine (186), low conductance, or lack of permeability to bivalent cations (187) suggests that these are probably not RyR in the PM.
