However, no long-term trials reported renal outcomes in type 2 diabetic patients, and the results on such end points are lacking in those trials with ivrabradine.
RUCAM has additional limitations when used in the setting of clinical trials for new drugs: RUCAM requires previous information on the hepatic effects of the drug, which is often lacking in clinical trials, especially in early phases.
Despite this, reports of external validity are lacking in many trials[ 6, 10, 12].
8 Evidence is lacking in human trials in terms of the relationship between skin cancer risk and immunosuppressive agents.
RUCAM requires previous information on the hepatic effects of the drug, which is often lacking in clinical trials, especially in early phases.
Lacking in experimental clinical trials, the best-available evidence to support the supposed tensile strength of repaired tendon at various stages of tendon healing is derived from laboratory experiments.
Unfortunately, this information is often lacking in reports of trials.
As noted above, the current literature is lacking in randomized clinical trials addressing the development of the dental and craniofacial complex and its possible influence on the morphology of the cranio-cervical and vertebral column.
Normative data for trial instruments are often lacking in cultures where clinical trials are conducted and cutoff scores for study entry as well as expected performances for healthy elderly persons may be difficult to extrapolate from Western experience.
The death penalty was used repeatedly, mainly in the 1960's but also last spring, in trials woefully lacking in due process.
