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Comparable data are lacking in kidney transplantation.
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Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in nondialyzed patients with chronic kidney disease (CKD).
It was full of phrases like "tissue engineering" and "therapeutic cloning", populated by people who excitedly talked of growing miniature kidneys and making embryos, and slightly lacking in a wholesale consideration of the moral aspects of genetic mechanics.
Rather lacking in fizz.
Interestingly, mice lacking ACVRIIB show abnormalities in kidney development and in anterior/posterior patterning of the axial skeleton show abnormalities(Oh and Li 1997; Esquela and Lee 2003), further emphasizing functional importance in the renal progenitor population.
Indeed, the ureteric bud had invaded the metanephric mesenchyme and branched once by embryonic day E11.5 in kidney rudiments lacking both Grem1 and Bmp7 (Figure 3A).
For the human kidney, concrete data are lacking, but in the neonatal rabbit kidney, approaching of epithelial and mesenchymal stem cells is prescribed by microfibers that link the inner side of the organ capsule with the tip of the CD ampullae (Fig. 2b).
Notably, the UUO kidneys with Mas receptors showed occasional glomerular collapse (arrowheads) that was not observed in kidneys lacking the receptor (Figure 1C).
Therefore, very few nephrons develop in kidneys lacking both Grem1 and Bmp7 and the resulting dysplastic phenotype is indistinguishable from the one of Bmp7-deficient mouse embryos.
While most dietary Al is removed by the kidneys, those lacking mature or patent kidney function such as pediatric and geriatric subjects may be more likely to accumulate Al in different organs, including the CNS.
Moreover, mRNA in situ experiments demonstrate loss of mRNA encoding the ubiquitously expressed subunits A1 and E2 in kidney epithelia that lacks Foxi1.
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