Induction of Akt transgene was restricted to DTG muscle, while STG controls with either the TRE-myrAkt1 or MCK-rtTA transgenes lacked conditional Akt activation (Fig. 2D).
Konrad Zuse's Z3 was the world's first working programmable, fully automatic computer, with binary digital arithmetic logic, but it lacked the conditional branching of a Turing machine.
Future studies aimed at addressing this question will necessitate the generation of EBs lacking VE or the conditional ablation of VE from established EBs.
Conditional mutants lacking both Cdc55 and securin/ Pds1 cleave cohesin prematurely, implicating Cdc55 as a regulator of cohesin cleavage (Clift et al. 2009).
In order to assess interneurons, we used the Dlx5/6- Cre (Stenman et al., 2003) line to generate conditional mice lacking Gsk3 in GABAergic interneurons.
Conditional models lacking Fxn primarily in the pancreas (Ins2-Cre; Table 1) were generated to model the pathophysiology of diabetes mellitus associated with FRDA (Ristow et al., 2003) (Table 1).
Mutants investigated thus far include the Fig4 plt/plt mouse (a spontaneous mutant with global Fig4 loss), the Fig4 Floxed/Floxed, Syn-Cre conditional mutant lacking Fig4 specifically in neurons and the Fig4 plt/plt, NSE- Fig4 tg) mouse overexpressing Fig4 specifically in neurons under the control of the neuron-specific promoter NSE.
As the conditions are frequently life threatening and lack existing treatment, conditional marketing approval may be granted on the basis of limited data or under exceptional circumstances.
In an inducible, conditional mouse line lacking NMDARs in DA neurons, the insertion of GluA2-lacking AMPARs and conditioned place preference were dissociated.
Therefore, conditional knockout mice lacking S1P1 selectively in nociceptive neurons of the dorsal root ganglion (DRG) were generated using the Cre recombinase loxP strategy and conditional removal of exon 2 (Fig. 5A) which encodes the entire coding region of S1P1 [42].
