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In COUP-TFII mutant mice, vessel growth is dampened, rendering tumor cells lacking blood supply and undergoing apoptosis or necrosis [ 6, 19].
After excluding 101 participants meeting the exclusion criteria and 107 participants for lacking blood samples, 2498 participants were finally included in the current analysis.
At embryonic day 9.5 (E9.5), COUP-TFII null mutants display a severe defect in angiogenesis as evidenced by the observations that the primitive capillary plexus fails to undergo remodeling to generate large and small microcapillaries as well as the inability of the capillary to invade into areas lacking blood vessels [ 15].
In the context pronephric development and embryonic blood flow, studies by Serluca et al. show that zebrafish mutants lacking blood flow as a result of cardiac defects fail to form a glomerular capillary tuft, indicating that while the phenotype is renal the underlying cause of the phenotype may be cardiac disruption [ 49].
Similar(56)
They lack blood for fighters injured in air strikes or on the frontline.
The most delicate filigree underpinned her at just the right moments, but that's not to say her performance lacked blood; far from it.
Perhaps because of its unusual format, perhaps because it lacked blood and guts, perhaps because its author was unknown, "The Gallery" was initially a hard sell.
To clarify this aspect we compared VE-cadherin morphants with silentheart (sih) morphants that lack blood flow due to complete impairment of cardiac contractility.
These non-proliferating regions always lack blood vessel support and contain numerous necrotic/apoptotic cells as well as rich lymphocyte infiltrating (Figure 3).
Angiogenesis: flies lack blood vessels.
By and large, they lack blood vessels, papillary muscles, valves, trabeculations, etc.
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