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Doré's team had discovered that mice lacking an enzyme called heme oxygenase recovered poorly from stroke.
The team, led by molecular biologist Brian Kennedy of the Merck Frosst Center for Therapeutic Research in Pointe Claire-Dorval, Quebec, and biochemist Michel Tremblay of McGill University in Montreal, created a line of mice lacking an enzyme called protein tyrosine phosphatase-1B (PTP-1B).
Several animal models have been generated to study the pathogenesis of CDG IIc: FX locus null mice, lacking an enzyme in the de novo GDP-fucose synthesis pathway [5], Gfr (homologous to FUCT1) null flies [6] and Fuct1 null mice [7].
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In this case, a fatty molecule, sphingomyelin, accumulates because patients lack an enzyme needed to degrade it.
At Harvard, they bred genetically manipulated mice that lacked an enzyme called telomerase that stops telomeres getting shorter.
He showed humans lack an enzyme in their liver required for making the vitamin, while almost all other animal species have this enzyme and thus do not develop scurvy on a Vitamin C deficient diet.
Some strains of one bacterium (Escherichia coli), for example, are able to synthesize the vitamin thiamin from simple compounds; others, which lack an enzyme necessary for this synthesis, cannot survive unless thiamin is already present.
These individuals are genetic males who remain female in form until puberty because they lack an enzyme necessary to bind two atoms of hydrogen to the male hormone testosterone, which is responsible for male sex characteristics.
The kind of phosphorous found in pig chow goes right through pigs because they lack an enzyme called phytase.
They found that mice that don't make ceramide because they lack an enzyme called acid sphingomyelinase (asmase) are protected from the damage.
Karin's team created mice that lacked an enzyme called IKKß, which is known to activate NF-κB, in the colon's epithelial cells, where colon cancer starts.
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