Sentence examples for lacking activity from inspiring English sources

Thus, we hypothesized that fMLP, although lacking activity as a chemoattractant for microglia, may activate microglia and cause inflammation-related DA toxicity similarly to substance P. The results given here demonstrate that fMLP (10−13 M) is selectively toxic to DA neurons after 8 days of treatment in primary rat mesencephalic N/G cultures.

We observed media-dependent effects in four systems: yeast one-hybrid experiments using either the Gal4 activation domain, wild-type Ubx, or a Ubx mutant lacking activity, and finally yeast two-hybrid experiments reporting on the p53·T-antigen interaction.

Jnk1 −/− Jnk2 −/+ mice (lacking activity of members of the Jun N-terminal Kinase, JNK, group of mitogen activated kinases) exhibit coloboma associated with loss of Shh and Bmp4 signaling, and reduced levels of Pax2, while addition of Bmp4 restored Shh and Pax2 expression (39).

In a study just published in the nanotechnology journal Small, the team describes the linking of an easily imaged, FDA-approved iron-rich nanoparticle, ferumoxytol, to a prodrug (a compound that, while lacking activity on its own, can get converted in the body into a potent drug).

(B ) Detection of wild type FLAG-LPCAT3 or a H374A mutant lacking activity.

Lacking activity in standard MIC testing, azithromycin (AZM), the most commonly prescribed antibiotic in the U.S., is never recommended for MDR GNR infection.

We were unable to identify active substrates for KDAC2 or SIRT1 that lacked activity toward KDAC3/SMRT.

DNA is a highly programmable molecular building block but generally lacks activity for signaling cells.

Aluwihare, P. et al. Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice.

Our best inhibitor has an IC 50) = 0.15 μM on MtDXR but still lacked activity in a mycobacterial growth assay (MIC > 32 μg/mL).

Ertapenem naturally lacks activity against A. baumannii.