Sentence examples for lack of variants from inspiring English sources

Alternatively, the small sample size analyzed could be the reason for the lack of variants.

A comparable pattern of variant distribution as well as a lack of variants on the short arm of maize chromosome 6 in the nucleolus organizer region (NOR; approximate position 7 28 Mb) has been reported previously [ 18, 19].

The lack of variants in PI4KA in a single patient with 22q11.2 deletion and PMG does not rule out PI4KA's involvement in this aspect of the variable phenotype as our analysis did not exclude that there may be functionally relevant non-coding variants in the remaining copy of this gene.

Given that this group of patients comprises a heterogeneous cohort representative of a variety of syndromes of extreme insulin resistance, the lack of variants affecting the protein sequence suggests that functional mutations in the genes ADIPOR1 and ADIPOR2 are not major causes of extreme insulin resistance in humans.

The package does not yet implement the full recommendations: important limitations, which are detailed in the issue tracker, include lack of variant canonicalization, the inability to represent compound, mosaic and chimeric variants and lack of support for inversions.

Because splice variants are confirmed with EST sequences, the lack of splice variants in the other studied insect pacifastin genes can be due to a limited availability of EST sequence data.

To investigate whether the better glucose tolerance phenotype in the offspring of long-lived individuals is due to lack of genetic variants associated with type 2 diabetes, we analyzed 15 well established type 2 diabetes variants in the Leiden Longevity Study [ 13] for their association with familial longevity.

Although many loci and genes have been suggested to be linked to schizophrenia, a low replication rate and a lack of functional variants to the risk to schizophrenia have greatly weakened our confidence in the common disease/common variant hypothesis.

Instead, the population structure observed in the African and Asian samples is expected to generate a deficit of rare alleles (and an excess of common alleles), and therefore, our results reporting an excess of rare alleles (or the lack of common variants) are conservative in light of our sampling strategy [25].

The Watterson's estimator of nucleotide diversity ( <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0014782.e001.PNG" class= inline-graphic"/> ) was modified in order to take into account important characteristics of the data (pooled DNA, sequencing errors and the lack of rare variants).

To further assess if the lack of common variants downstream of intron 6 may be due to natural selection at inter-specific level, we applied the Kolmogorov-Smirnov statistic (KS), which belongs to a family of statistics that test if the ratio of polymorphism to divergence along a gene is homogenous, as expected under neutrality [36].