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Only a quarter of recorded attacks have lead to charges being brought, for fear of a repeated attack or a lack of trail for police to pinpoint attackers.
Control cells also showed a lack of TRAIL induced caspase-8 processing to p18.
TRAIL protein detection was mostly negative or only focally positive in isolated tumor cells in both primary and metastatic OSCC tumors, and our Western blot analysis clearly demonstrated the lack of TRAIL protein in primary and metastatic OSCC cell lines.
The lack of TRAIL mediated killing in these other cell lines may result from several possibilities, such as insufficient death receptor expression (DR4 and DR5), the glycosylaton state of these receptors or high decoy receptor expression [ 33, 34].
To deny the possibility that the lack of TRAIL receptors of #63 cells occurred in vitro during repeated culture, we examined the expression of TRAIL receptors of original tumour tissue.
Although our results using an antagonistic anti-TRAIL-R2 Ab support a potent mechanism of TRAIL resistance of #63 cells because of the lack of TRAIL receptors, the possibility that genotoxic agents may modify the signal transducers downstream of the receptors has to be elucidated.
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BT20 and MDAMB468 cells were insensitive to TRAIL (10 ng/ml), as shown by the lack of TRAIL-induced apoptosis in mock-transfected cells.
Because TRAIL needs to directly contact the TRAIL receptors on the tumor cell surface to induce apoptosis, lack of infiltration of immune cells into the tumor may result in lack of TRAIL-induced apoptosis of the tumor cells.
The lack of paper trail for electronic voting, however, is generally considered a bit of a nonstarter, and recent events will likely only make security experts more wary of adopting new tech.
Among their findings, Deloitte maintains that out of the $104 million funneled by the feds to the band between 2005 and 2011, there's a serious lack of paper trail tracking how it was spent.
Tuscany, for example, is a haven for bikers, but the busy roads and lack of walking trails make it less ideal for a walking holiday.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com