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Transplantation of GsnWT epithelium into the Gsn−/− fat pad recapitulated the lack of terminal branching seen in Gsn−/− females.
Second, after the mammary epithelium had filled the mammary fat pad, a complete lack of terminal branching, or late block, was observed (Gsn−/−LB).
Loss of UPF2, initiated from the early stages of hepatoblast migration and onwards, resulted in relative minor phenotypes, the main being the lack of terminal differentiation of fetal liver cells at a stage beyond the HNF4α-dependent epithelial transformation.
The lack of terminal cell death in vivo may be alternatively explained by the rapid clearance of dead cells by macrophages, thus we used the fluorogenic caspase-3 substrate PhiPhiLux to purify OVA-specific CD8+ T-cells at day 5 of infection into active caspase-3hi and caspase-3low fractions (Fig. 5A).
Erythroid cell dysplasia observed in MDS is due to a lack of terminal erythropoiesis and increased apoptosis.
This lack of terminal galactose is associated with a poor prognosis in the course of the disease [ 48].
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However individual schools are likely to face logistical challenges switching to computerised exams because of a lack of terminals.
They have failed dismally because of a lack of terminals and the reluctance of customers to add yet another piece of plastic to their already bulging wallets.
Many trials in the U.S. have failed dismally due to a lack of terminals and the reluctance of customers to add yet another piece of plastic to their already bulging wallets.
We generated homogeneous cultures of NS cells that express immature neural precursor markers (like Sox-2 and Nestin) and lack markers of terminal neuronal (Beta-III tubulin) or glial (Gfap) differentiation (fig. 1a).
The lack of a terminal GU penalty may arise from the flexibility of a terminal GU pair which allows optimization of hydrogen bonding and stacking interactions without incurring the energetic penalty associated with an interior GU distorting the backbone.
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