Sentence examples for lack of target specificity from inspiring English sources

Hasinoff, B. B. The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity.

Specifically, nanoparticle-based drug delivery systems have enormous potential in addressing the failures of traditional drugs that could not be effectively formulated due to factors such as poor water solubility or a lack of target specificity [1 3].

These inhibitors reportedly produce side effects in clinical settings primarily due to the lack of target specificity and/or selectivity.

Although CCCs are attractive drug targets, bumetanide and other existing CCC inhibitors are suboptimal because of pharmacokinetic constraints and lack of target specificity.

However, LiGABAR enables advanced investigations that aim to explore a specific receptor and/or neuron subtype in a complex system, which cannot be achieved with existing optopharmacology agents because of their lack of target specificity.

However, there is a clear need to develop strategies to overcome the critical limitations of peptides, such as poor solubility and the lack of target specificity, which impede their clinical applications.

Traditionally, any drug intended for combating the tumor would distribute profoundly to other organs and tissues as lack of targeting specificity, thus resulting in limited therapeutic effects toward the tumor but severe drug-induced toxic side effects.

However, the lack of targeting specificity leads to severe side effects such as hemorrhage (Manuscript and Factors 2008).

It is thus not surprising that lead's toxicity is not specific to the brain and we do not believe this lack of target organ specificity diminishes the inference for a causal relationship between lead and cognitive dysfunction.

DNA probes however implied that the method suffers from limitations related to cell permeability, hybridization affinity and target site accessibility, leading to poor signal-to-noise ratios and lack of target site specificity and sensitivity [21], [23], [25].

Disadvantages include the lack of target cell specificity, potential of immunogenicity, and our incomplete knowledge of the molecular mechanisms of protein transduction.