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More than 4,000 V6-tags were shared in coral and seawater libraries (Figure 1A), thus a lack of sequencing depth was a likely reason for the apparent absence of overlap between coral- and seawater-associated bacteria in previous studies.
It is possible that we missed variants in these exons due to lack of sequencing coverage.
Lack of sequencing data for individuals with TC ≤ 9.3 mmol/L prevents the analysis of the true sensitivity/specificity of the FH diagnosis in these individuals.
The enrichment for both testis and brain-specific miRNAs in this dataset partially excludes lack of sequencing depth as a confounding factor.
A large portion of this likely came from environmental heterogeneity and differences in animal history, combined with lack of sequencing depth.
Population-level heterogeneity was clearly present, although the lack of sequencing depth weakens conclusions about gene content homogeneity within the symbiont populations.
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Despite the lack of sequence homology, Mac-1 adopts the canonical papain fold.
This is in agreement with the secondary structure predictions and the lack of sequence conservation among the linker domains in HPFlong (Supplementary Figs. 9 and 10).
Despite this lack of sequence discrimination by NF-κB, an AATTY motif is overrepresented in the spacer region in its genomic response elements35.
Despite this lack of sequence-distant contacts, ankyrin repeat polypeptides have been shown to fold in a cooperative manner.
However, lack of sequence similarity between the mammalian and the yeast protein X homologues suggests they are not biochemically equivalent.
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