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We suggest that a variety of factors contributes to the lack of sensitizing activity of the remaining six bacterial mutagens: extremes of intrinsic chemical reactivity, high water solubility reducing dermal translocation, and inappropriate dermal metabolism.
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Current test of sensitizing chemicals rely on animal experimentation.
They attributed the lack of reactivity and sensitizing potency to the α-methyl substitution of the α-β-double bond.
We have shown above that the lack of UDG activity sensitizes tumor cells to antimetabolites.
These findings may be explained by some reports stating that lack of calpain activity could sensitize cells to programmed cell death due to a variety of stimuli, including growth factors and nutrient starvation [ 30].
A lack of proper initial buffering may sensitize DTCs such that their subsequent migration is no longer robust.
However, there was also study showing that lack of SCD-1 activity would sensitize hepatocyte to SFA-induced apoptosis and render mice lack SCD-1 vulnerable to liver damage other than steatosis [ 23].
Interestingly, lack of ICL repair recently was shown to sensitize murine HSCs to damage caused by endogenous aldehydes (Garaycoechea et al., 2012).
His time in detention in the United States had sensitized him to prison conditions and to the lack of prisoners' rights in Haiti.
We have previously reported that a number of SCLC cells are resistant to TRAIL treatment owing to the lack of caspase-8 expression, and restoration of this protease is sufficient to sensitize these cancer cells to TRAIL.
Travelling sensitized me to see the persistence of problems such as a lack of universal health care or lack of clean water in some African nations as examples of global irresponsibility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com