Sentence examples for lack of secretion from inspiring English sources

Moreover, the similarity of the behavior of R105W mutant and cystein mutants suggests that the lack of secretion observed with the naturally occurring mutant could result from impaired disulfide bond formation.

We showed that the lack of secretion in the proximal, visible part of the ETT does not exclude a relevant loss of cross-sectional area in the endotracheal portion, whose presence can be clinically disclosed only by bronchoscopy.

By generating plasmids encoding p.L72A, p.L72I, p.L72V, or p.L72T leptin and transfecting these plasmids into HEK293 cells, our group was able to determine the lack of side chain hydrophobicity at position 72 of the protein as the main cause for the lack of secretion [20].

This is followed in many cases by acute symptoms caused by lack of secretion of essential hormones, predominantly adrenal insufficiency.

In pituitary apoplexy, the main initial problem is a lack of secretion of adrenocorticotropic hormone (ACTH, corticotropin), which stimulates the secretion of cortisol by the adrenal gland.

In contrast, lack of secretion of EspPβ from the prototype strain 89/04 [16] does not result from modifications on protein level, but is caused by impaired gene expression.

The proportion of insulin resistance versus beta cell dysfunction differs among individuals, with some having primarily insulin resistance and only a minor defect in insulin secretion and others with slight insulin resistance and primarily a lack of insulin secretion.

So far, BFA is the only inhibitor known to block reelin secretion [11], thus we treated hippocampal cultures with BFA to assay the physiological consequences of the lack of reelin secretion.

The lack of detectable secretion from wild type Salmonella is inconsistent with SseK3 being a secreted effector, although the low expression level of SseK3 may have precluded its detection.

Insulin granules were docked, but the lack of insulin secretion suggested an inability of granules to fuse at the plasma membrane of pancreatic β-cells.

b In CF airways, the acidic ASL, caused by a lack of bicarbonate secretion through dysfunctional CFTR, causes SPLUNC1 to adopt an inappropriate conformation, where the ENaC inhibitory domain (also known as the S18 region) cannot bind to ENaC, leading to Na+ hyperabsorption and ASL dehydration.