The ectopic expression of Zic2 in cRGCs leads to a lack-of-refinement phenotype of their axons, a defect that is partially reverted after application of fluoxetine indicating, at least in part, this phenotype is caused by induction of Sert.
Once shunned because they weren't refined, it is their whole lack of refinement, or processing, which makes them valuable.
It is true that wire has never quite mellowed into the western landscape: the very name still preserves, as Walter Prescott Webb wrote in 1931, "something suggestive of savagery and lack of refinement the relentless hardness of the Plains".
There's some brazen playing to enjoy – the low brass in March to the Scaffold sound like a foghorn – but the impression of a lack of refinement is deceptive: the balance and pace are always tautly in check.
Her work as a fork-lift operator and a welder is a tossed-off line of dialogue; her interests are undefined; her ostensible lack of refinement is merely a matter of her loud voice and salty vocabulary; her relationships are utterly vague, as is her wider network of interactions, of friends and relatives and colleagues and rivals.
Ultimately, it was the lack of refinement which tipped the balance to Owens.
Actually, the problem didn't seem to be a lack of refinement.
The window sticker and warranty are undeniably attractive, but you pay the price in a lack of refinement.
The worrying thing for the manager is that the lack of refinement has become a recurring theme.
It is the lack of refinement in possession that can be startling and the tendency to rush passes.
