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It has been suggested based on a variety of functional assays that the lack of reducing power and the need to up regulate glutathione biosynthesis were the major reasons for ATF4 induction in mouse under secretion stress conditions [ 13].
In metabolic terms, this equates to a lack of reducing equivalents to drive cellular processes, a prominent increase in NAD/NADH ratio, and, thus, a marked imbalance in cellular redox state.
In this current study, reducing cofactors were regulated by de novo synthesis pathway with the addition of precursor l-tryptophan, which increased the level of NADH and NADPH and possibly complemented with the lack of reducing cofactors in the alcohol-dependent pathways of strain BOH3.
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Despite its lack of sexiness, reducing energy demand through insulation, smart meters, double-glazing and efficient appliances "offers the best and most cost-effective chance to mitigate the worst effects of climate change", according to the UK Green Building Council.
In essence, the induction period was initiated with a slow autocatalytic rise in the number of nuclei due to the lack of sufficient reducing agent in the solution.
However, a 10% reduction of our data is expected due to lack of compliance, reducing the data available for full analysis to 1,800 adults.
This lack of injury reduced bacterial translocation, and would presumably reduce the incidence of sepsis.
By 1909 a lack of commissions reduced him to desperate straits; he was forced to sell his library and household effects.
The buildings that are subject to the lawsuits -- 40 Broad Street, Parc East Tower and Worldwide Plaza -- were chosen as representative of the three major categories of violation: lack of amenities, reduced access and annexation by commercial tenants.
Hydrocortisone increases protein breakdown, and consequently the output of nitrogen in the urine, and affects water metabolism; lack of hydrocortisone reduces the power of the kidney to deal with normal water loads.
Unfortunately, a lack of time reduces non-business relationships.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com