Sentence examples for lack of reading frame from inspiring English sources

Due to the modularity of transcription factor binding site clusters and the lack of reading frame constraint, promoters are more evolvable than coding regions [ 1, 2].

Lack of reading frame cannot also be a discriminating factor between mRNAs and ncRNAs because 50% of lincRNAs contain regions with high translational potential, comparable to those of mRNAs, suggesting that they are actively exported to cytoplasm and translated into short polypeptides, albeit certainly not active.

Owing to their lack of reading frames, lncRNAs were originally considered as transcriptional noise.

The 7,500 sequences identified with the lowest E values (which represent the best similarity to known genes) were uploaded to eArray (Agilent Technologies, Palo Alto, CA) in both forward and reverse sequence orientation (due to lack of reading-frame information to assess the "sense" strand).

Together the non-protein-like features, loss of reading frame and lack of protein evidence suggested that many of these genes might not code for proteins under normal circumstances.

Alternatively spliced TCR mRNA induced by disruption of reading frame.

Due to the lack of an open reading frame (ORF) or other features required by current gene recognition algorithms, it has been proposed that most of the miRNAs are expressed from independent transcription units [10].

Low-confidence genes were characterized by (1) having no or only weak sequence homology to reference proteins and no predicted function, (2) they were candidates for transposons or (3) they lacked an open reading frame of a minimal length (Supplementary Note 3).

Recently a number of complete baculovirus genome sequences have been described and were found to lack an open reading frame with homology to gp64.

The highly fragmented nature and lack of intact open reading frames of the Helitrons identified further supports the idea of lack of active transposition.

To reconstruct the evolutionary history of the NANOG gene and its pseudogene family with source-gene mutation analysis, we aligned the reading frame of the human and chimpanzee NANOG gene with the corresponding sequences in all pseudogenes (except NANOGP11, which lacks the reading frame), and corrected (in all but four cases) post-H/C divergence mutations to reflect the ancestral sequence.