In ER+, PI3K mutant breast cancer cells, this negative edge dampens (but does not block) ER signaling, and all four other pathways are active; yielding the collective effect of a significant proliferation propensity and lack of apoptosis propensity.
The extinction of Neanderthal man has been attributed variously to his having lower intelligence than modern humans, to worse language skills, to cruder tools, or even to the lack of a propensity for long-distance trade.
The lack of a propensity for interactions with phenotypically essential proteins suggests a selective pressure to minimise virulence in retroviral evolution.
Random positioning and the apparent lack of sequence propensity are suggestive of sequence-nonspecific DSB mechanisms such as oxidative free radicals, ionizing radiation, or less commonly, spontaneous DNA backbone hydrolysis.
He hoped her radical philosophy would inspire a generation of strong, assertive women, even if her costume (or lack of it) and propensity to bondage provoked criticism from the start.
BP Chief Executive Tony Hayward displayed a shocking lack of empathy and a propensity for public gaffes while the Deepwater Horizon rig was spilling millions of barrels of oil into the Gulf of Mexico.
To minimize the bias resulting from the lack of randomization, a propensity score will be used.
Sweezy, a six-foot-five, two-hundred-and-ninety-odd-pound defensive tackle, was knocked by scouts for his weak upper body, his lack of flexibility, and his propensity for meathead antics, which allegedly included a drunken altercation with a sixty-five-year-old bus driver.
Lack of perseverance and the propensity to revert to traditional practices when difficulties were encountered (Su 1994).
Our clients are not paralyzed by lack of confidence or a propensity to resist change for the better.
The adoption of wheat straw as a fuel for gasification processes has been hindered due to a lack of experience and its propensity to cause bed agglomeration in fluidised bed gasifiers.
