This analysis is based on the use of preliminary data.
When I first started this work, my grant renewal application did not get a fundable score because of the risky nature of the project and the lack of convincing preliminary data.
However, because of its lack of toxicity and preliminary data showing some activity in other types of cancer, combination of IM862 with other drugs such as chemotherapy or biologic agents could be worth considering, especially if a biological effect such as the decrease of VEGF levels could be confirmed.
However, a more detailed structure-activity relationship study to reveal the contribution of specific structural elements, for instance length of the aliphatic side chain and position of the heterocyclic nitrogen, is lacking and preliminary data indicated that substitution of bromine by other halogens might lead to more active compounds [ 54].
Although studies focusing specifically on psychiatric complications of DAAs are lacking, this preliminary data suggests that DAAs confer a minimal risk of additional neuropsychiatric side effects.
For instance, information on the biological significance of the E7 expression in these tumours is lacking, but preliminary data indicate that the presence of E7 can improve cell growth rate.
If you lack preliminary data to prove that your system or model is valid, then you need to generate the data before you resubmit.
The NRC report inspired another of the initiatives: a new grant competition at the National Institute of Environmental Health Sciences (NIEHS) for investigators lacking enough preliminary data for a full-fledged NIH proposal.
Possible patient factors contributing to missing such data include lack of patient recognition of stroke symptoms, symptom onset during sleep, cognitive impairment upon presentation, and lack of preliminary evidence of cerebral infarction.
Much of the preliminary data confirms already known issues affecting a large number of forced migrants in the region.
