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A completely non-invasive approach for neural modulation would be ideal, but it may prove to be difficult due the lack of precise control in mapping or stimulating specific regions of the brain without intervention.
Thus, a lack of precise control of these parameters across subsequent TMS/hd-EEG sessions, may result in large measurement errors and in an apparent modulation of cortical responsiveness.
What makes it difficult to distinguish clearly between GJIC mechanisms and other mechanisms of transfer in cells exposed to chemicals or radiation is the lack of precise control over the regions of cells directly exposed.
Particular problems include: I) lack of precise control over network component concentrations, II) unpredictable interactions and integration with host cell processes, III) cumbersome molecular cloning, and IV) technical challenges and limited throughput associated with single cell measurements.
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The lack of precise temperature control in a microwave means that it's not ideal for meats, fish or egg dishes, which toughen when slightly overcooked.
Although this method suffers from a lack of precise experimental control, it exemplifies the ease with which the cations can diffuse into the inorganic framework.
However, lack of precise experimental control over important matrix factors in these matrices have increasingly led investigators to synthetic and semi-synthetic scaffolds that offer the engineering of specific ECM cues and the potential for more advanced experimental manipulations.
Lack of precise temperature control and the potential for pulmonary edema however, make this modality unsuitable for the maintenance phase of hypothermia [ 14, 15].
However, some problems remain: (1) The CMC preparation procedures are time-consuming, especially the membrane extraction steps, and some key parameters, e.g., content of maximum binding protein, lack precise control.
However, their precipitation methods not only lack precise control over the morphology and size of final products, but also induce reunion reaction of AgCl [34].
Current strategies for BBB opening are invasive, not specific, and lack precise control over the site and timing of BBB opening, which may limit their clinical translation.
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