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Some military analysts go beyond the lack of Phase IV planning and more generally blame the Bush administration's insistence, upon coming into office, that it would no longer commit American armed forces to nation-building missions -- a position symbolized by the decision, now being reconsidered, to close the Peacekeeping Institute at the Army War College in Carlisle, Penn.
Furthermore, due to lack of phase II non-inferiority trial design methods, we do not have an opportunity to investigate the efficacy of the experimental therapy through a phase II trial.
DWT has three serious disadvantages [26]: shift sensitivity, poor directionality and lack of phase information.
Signal losses due to imperfections in RF pulses and lack of phase rewinders were offset in this sequence by reduced diffusion losses incurred with the gradients required for MR microscopy.
In the lack of phase information, combining data at different loci is advantageous to minimize noise [35], [36].
However, we still lack of phase III trials comparing second-line chemotherapy vs best supportive care.
Similar(47)
Cold permafrost, in turn, is more responsive to changes in air temperature owing to the lack of phase-change effects and a usually thinner buffering cover of vegetation and snow15,95.
Haplotype-based association mapping could possibly address these last two points, however the low number of SNPs per gene, the lack of phased data, and the low linkage disequilibrium within teosinte (A. L. Weber and J. F. Doebley, unpublished results) make this strategy difficult to implement and unlikely to yield more power.
A new analysis is referenced in the Introduction, and lack of phasing could easily result from random Pol IV initiation or DCL3 cleavage.
In contrast to CRM2, CRM1 lacked both the single-nucleosome peak at start-to-start distance 155 as well as the subsequent peaks every 190 bp, consistent with the lack of phasing seen in Figure 2B.
Owing to the lack of randomised phase III trials, there is a need to define treatment standards on predominately phase II trials.
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