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Another limitation of microarrays might be the lack of pathway knowledge.
Previously published isolated instances of intersource discrepancies include the lack of pathway source consensus for the TCA cycle (3) and fatty acid metabolism (2).
The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity.
The failure to detect all genes from these pathways could be explained by a lack of transcriptome coverage and/or by a lack of pathway documentation of these specific genes [ 25].
Similar(56)
Although many diverse variants are demonstrated to converge on similar deregulated pathways, there is still a lack of pathway-targeted therapies.
Three major differences involving the lack of pathways of genes between E. cymbalariae and A. gossypii were found.
Lack of pathways and dangerous traffic were among the reasons many parents did not allow their children to walk or cycle alone.
As expected by the lack of DAP pathway, all those bacterial (micro organisms biosynthesizing lysine through the AAA pathway (T. thermophilus, D. radiodurans) do not have diaminopimelic acid within their cell wall [ 41, 42].
Simply pooling several pathways sources would result in redundancy and the lack of systematic pathway interrelations.
We have shown that, at least in the airway epithelium, the inability of the Toll-pathway to function properly, is due to the lack of vital pathway members [ 7].
Because of the lack of other pathway components between Patched and Ci, there is little doubt that there is no bona fide Hh signaling pathway in C. elegans [ 4].
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