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It is considered that the poor results are due to the lack of parameters to model the 4-D light field for this complex light, and more input images are also necessary to acquire stable results.
Patients who died before day 7 were excluded because of lack of parameters concerning the evolution of diastolic parameters and echo-estimated LVFP.
Several approaches try to overcome the lack of parameters values by proposing dedicated qualitative modeling approaches (see [ 1, 2] for overview and [ 3] for review).
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The major disadvantage of the methods proposed in [13, 14] compared to the method proposed in [12] is the lack of parameter estimation.
High levels of variability in cancer-related cellular signalling networks and a lack of parameter identifiability in large-scale network models hamper translation of the results of modelling studies into the process of anti-cancer drug development.
In that context, the entropy method should be used as an initial scan of the copy number data due to its speed, in the order of seconds, robustness and lack of parameter calibration.
The lack of parameter identifiability in large-scale network models hamper translation of the results of modelling studies into the process of anti-cancer drug development.
However, because of a lack of parameter information and evidence for the biological mechanism, we abandoned this approach for the present version.
Furthermore, it can be argued that the lack of parameter effect demonstrated for RVLP clearance is applicable to all model viruses (X-MuLV, MMV and SV40).
Due to the correlation observed between X-MuLV and MMV LRVs, it is expected that the lack of parameter impact on RVLP removal within the parameter ranges studied can also be generalized to other model viruses.
For ordinary differential equation (ODE) models, the challenge in this estimation has been attributed to not only the lack of parameter identifiability, but also computational issues such as finding globally optimal parameter estimates over highly multidimensional search space.
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