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However, the lack of normalization of the information handled in and exchanged between such services hinders the scalability and extendibility.
This lack of normalization and centralization hinders the large-scale integration of brain connectivity results.
However, these methods are not generalizable because of the lack of normalization across datasets ('t Hoen et al. 2013; Broman et al. 2015).
Such a proposal would have to account for the lack of normalization effects found in Experiments 2, 4a, and 4b and for the reduction of the effect in Experiment 4d, as compared with Experiment 1a.
Despite this, it is important to note that the lack of normalization approaches for RNA-Seq, makes identification of rare, cell-type specific transcripts challenging, as highly expressed transcripts would obtain the most tag coverage.
This suggests that the lack of normalization results in the extreme over-representation of a few transcripts (50% of reads map to 0.98% or 2.47% of all unigenes with mapped reads in LDN and RSL65, respectively).
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One possible explanation was that the data distributions of the replicated data sets were not well centered due to a lack of data normalization.
The lack of complete normalization by insulin treatment offers the potential that these proteins may play a role in the 'metabolic memory' [78] observed clinically in retinopathy pathogenesis [79].
The lack of a normalization effect in Experiment 2 was thus apparently not due to an insufficient match of spectral properties between the precursors and targets in those materials.
As drugs are registered in the FAERS by arbitrary names, e.g. trade names and abbreviations, and may even contain typographical errors, the lack of drug normalization introduces substantial barriers for data integration in signal detection.
From a more experimental point of view, the lack of appropriate standardization or normalization methods between laboratories has hindered the comparison of PRP with PRF in wound-healing investigations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com