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We find that while lack of mouse α-synuclein in mice is associated with reduced vulnerability to MPTP, increased levels of human α-synuclein expression is not associated with obvious changes in the vulnerability of dopaminergic neurons to MPTP.
However, the absence of cell lines derived from CLL patients that can propagate in mice, and the lack of mouse models of CLL that recapitulate the human disease have hampered the preclinical development of new therapies and treatment strategies for this disease.
Another issue with NEK2A research is the lack of mouse models.
The lack of mouse chromosome-specific probes causes problems for most genome-connected studies, including studies in developmental biology.
Lack of mouse click indicates no response or a stimulus that is not visible to the patient.
The role of HSP60 in pathogenesis of these diseases remains unclear, partly because of the lack of mouse models expressing HSP60.
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The Guardian reports that a spokesperson for the judge ruling on the case said that the experts found there were many things wrong with this excuse, one big one being the lack of mice corpses.
Importantly, two recent studies revealed lack of p19 (mouse homologue of human p14 ARF)) function in mice to inhibit p53 tumor suppressor function in response to ionizing radiation as well as DNA damaging agents [29], [30].
The lack of a mouse or touchscreen means the interface is clunky.
However, the lack of appropriate mouse models recapitulating the CID G/AI is a stumbling block to characterize the pathophysiology of this phenotype23.
A laptop's tiny keyboard, swiveling screen and lack of a mouse adds up to an ergonomic nightmare, and now doctors are reporting a surge in injured users.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com