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However, over the whole day these differences tend to cancel out, thereby accounting for the lack of meaningful differences between OD and BID dosing for AUC0-24h.
Due to sparseness of data and lack of meaningful differences in some routes of administration, intravenous injection and intramuscular injection were grouped into category of injection.
Lack of meaningful differences could be due to lack of benefit of CGM use on QOL, insensitivity of the measures to detect changes, or high baseline levels of QOL in this population yielding a ceiling effect.
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The Gallup report points out the lack of "meaningful difference" in the public's view of NCLB by political party, as Democrats and Republicans rated the law similarly across categories of effectiveness, "perhaps reflecting the broad bipartisan support" for the law when it passed through Congress in 2002.
Although differences in structure between a candidate biosimilar and its reference product will be evaluated in functional, nonclinical, and clinical studies to assess biosimilarity and to demonstrate the lack of clinically meaningful differences, the potential differential clinical effects between any two biosimilars of the same reference product will not likely be formally evaluated.
In addition, a lack of clinically meaningful differences between the biosimilar and the originator biologic needs to be demonstrated.
The lack of clinically meaningful differences in treatment effects related to baseline severity would suggest that it is legitimate to include low intensity interventions in the first step of a stepped care system and to encourage most patients to use them as the initial treatment option, even when initial severity of depression is high.
Giving people the choice of which diet and exercise regime is best incorporated into their particular lifestyle is expected to improve adherence, reflects real-world conditions, and is consistent with the lack of evidence for meaningful differences between diet modalities.
Lack of meaningful scale.
The lack of meaningful communication between departments gets in the way of effective public engagement.
"There is a lack of meaningful competition in retail banking in the UK.
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