Sentence examples for lack of islet from inspiring English sources

We investigated whether the A−β− subgroup of KPD, characterized by complete insulin dependence, absent β-cell functional reserve, lack of islet cell autoantibodies, and strong family history of type 2 diabetes, represents a monogenic form of diabetes.

Initially, E2-treated graft beta cells are non-functional and show no insulin-secretory response to the glucose challenge, probably as a result of hyperglycaemia-induced glucose desensitisation and/or lack of islet vascularisation.

The lack of cadaveric islets for transplantation determines that researchers must explore alternative sources of graft material.

Notably, however, isolated islet β-cells lack the presence of islet glucagon and glucagon-induced stimulation of β-cell adenylate cyclase is expected to suppress iNOS expression and activity [12], [13], [20].

This we showed by lack of precocious secondary islets in larvae treated with this drug.

Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function.

This is in contrast to diabetes mellitus type 1, in which there is an absolute lack of insulin due to breakdown of islet cells in the pancreas.

Tissue engineering strategy has been considered as an alternative treatment for diabetes mellitus due to lack of permanent pharmaceutical treatment and islet donors for transplantation.

This is reflected by robust expression of human UCN3 but lack of enrichment in either human islet cell type.

This discrepancy from the above result reveals that, during short-term culture, despite the lack of a significant improvement in islet survival between the PGA and sMG conditions, the sMG condition most likely improves the ability of the islets to promote insulin release, which may be attributed to the preferable dynamic features of sMG.

Diabetic ketoacidosis (DKA) is a life-threatening condition that occurs predominantly in patients with newly diagnosed type 1 diabetes mellitus and is a consequence of a lack of insulin production by pancreatic islet cells, but it may also occur in patients with type 2 diabetes with poorly controlled blood glucose concentration or other diseases [ 1].