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There also is a lack of general consensus about which patient groups should be investigated and the appropriate methodology that should be employed to identify whether clinical outcome differences between these two dosing approaches exist in all hospitalized patients.
The lack of general consensus on NP toxicity is due to different experimental methods employed, incubation conditions (concentrations and exposure time), variability of sizes and functionalities of GNPs, variability of cell lines, and different measures and assays for toxicity (Fratoddi et al. 2015; Haume et al. 2016).
Hence, its potential still remains partially unexploited, largely because of a lack of general consensus and public concerns regarding the lack of effectiveness and control, poor reliability, and possible occurrence of side effects, for example accumulation of toxic metabolites and pathogens.
Perhaps owing to the its theatrical "refusal to be 'original,'" there was a lack of general consensus as to what "good" vaporwave even sounded like.
Another critical issue that makes the biological role of H2S controversial is the lack of general consensus about subtle metabolic perturbation of H2S poisonings in urine and plasma.
Yet, there is a lack of general consensus regarding optimal rating scale format, including aspects of question structure, the number and the labels of response categories.
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Although Symbiodinium sequences are readily available from generic genetic databases, their usefulness is impeded by the lack of a general consensus on the classification of Symbiodinium species.
The lack of a general consensus on the classification of Symbiodinium species coupled with the variety of different markers used to identify the genus Symbiodinium (ITS1, ITS2, LSU D1/D2, chloroplast 23S rDNA and psbA minicircle) further complicate direct comparison.
It could also reflect the lack of a general consensus regarding the correct definition of the condition.
However, due to the lack of a general consensus on critical characterization parameters, a shortage of harmonized protocols to support testing, and the vast variety of engineered nanomaterials, the translation of nanomedicines into clinic is particularly complex.
Of course, it was supposed to be reauthorized in 2007, but what with partisan politics, outside influences and the lack of any general consensus around the various efforts, Congress has yet to successfully reauthorize the legislation.
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