Whether or not the lack-of-function phenotype of Mnn1 mutants can be accounted for by the disruption of the activity of Trx and TAC1 complex remains to be investigated.
While menin is required for Hsp70 expression, the results of epistatic studies indicate that the increase in genome instability observed in Mnn1 lack-of-function mutants cannot be accounted for by mis-expression of Hsp70.
Therefore, our study investigated a potential endogenous role of prion protein in synaptic signaling, the lack of which could resemble a lack-of-function phenotype in prion disease.
The lack of effect on telomere length in either TANK1−/− or TANK2−/− single knockout mice could also reflect functional redundancy rather than lack of function of these two molecules.
Midprice Portables Because of the expense of built-in systems and the lack of function of the smaller handheld units, midprice portable models are becoming popular.
Any mutation that results in a lack of function for a particular gene is called a "null" mutation.
"I'm a skeptic about the ability to transform Iraq into a democracy in any realistic period of time," Mr. Scowcroft said, noting the lack of functioning institutions and a surplus of ill will among different religious and tribal groups.
The book refers to a selection of uncomfortable truths that illustrate modern America's ailing infrastructure, ranging from bridge collapses and rail disasters to a chronic lack of functioning public transport options.
This could explain the lack of function common to many schizophrenics and the failure of those hearing voices to tag inner speech as coming from the self.
The shrilling of daytime TV only emphasises the lack of function of people whose wisdom – often forged in adversity and hardship – is of no use to succeeding generations, since they have been born in a later, wiser age, in which such knowledge is, like its possessors, redundant.
