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The protective effects of WT-MSCs were dampened by lack of endogenous PTX3, too.
This suggests that the lack of endogenous histamine could help to reduce sepsis-induced multiple organ injury.
Hormone replacement therapy (HRT) has been generally used in postmenopausal symptoms in women caused by a lack of endogenous oestrogen.
However, when used for brain glioma detection, the lack of endogenous contrast is a major limitation to the distinction between tumor and normal tissues through photoacoustic imaging.
However, lack of endogenous PTX3 seemed to reduce WT-MSCs effects (Additional file 1: Table S3), maybe by impairment of local cell-to-cell interaction.
Accordingly, there is a drive for approaches such as β-cell replacement therapy, which is a permanent replacement for the lack of endogenous insulin production.
Although the MVA pathway is energetically less efficient than the native methylerythritol 4-phosphate (MEP) pathway, implementing the MVA pathway in bacterial hosts such as E. coli is advantageous due to its lack of endogenous regulation.
No dominant-negative effect of kinase-deficient RSK2 was observed due to the lack of endogenous RSK2 in CLS cells.
All these data suggest that there is a lack of activation of PPARγ, caused either by a lack of endogenous ligands or by a loss of its functionality.
A major drawback of protein expression in bacterial hosts is the absence of eukaryote-specific co- and posttranslational modifications, e.g. due to lack of endogenous NMT activity.
The first group underwent a bilateral trans-scrotal orchiectomy to induce androgen deficiency and was labeled "A−" to indicate their lack of endogenous and exogenous androgens.
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