Exact(29)
Hierarchical testing showed no significance, indicating a lack of dose response across the 3 mesalamine doses.
Similar concentrations were found in farmed foxes and housed sledge dogs while the lack of dose response designs did not allow an estimation of threshold levels for oral exposure and accumulated tissue concentrations.
However, a quantitative microbial risk assessment (QMRA) has not been performed due to the lack of dose response models resulting from significant heterogeneity within even a single species or subspecies of MAC, as well as the range of human susceptibilities to mycobacterial disease.
Understanding this lack of dose response will be important for optimization of administration of PfSPZ Challenge.
A possible explanation for this lack of dose response may be trapping of PfSPZ at the inoculation site.
A search of the relevant literature indicates that this lack of dose dependency has been reported by others.
Similar(31)
The relatively comparable values in all treated groups suggests a lack of dose-dependent changes and a lack of consistent correlation with other pathological findings (e.g. histopathological or gross pathological findings), thereby implying an absence of target organ effects.
It is important to note that the lack of dose-dependent effects of γ-irradiation on protein secondary structures was also observed earlier under similar experimental conditions.
A more likely reason is the lack of dose-response relationship for DNA strand breaks and the high interanimal variation.
The lack of dose-response relationship may indicate a maximal rate of particle-induced DNA strand breaks was achieved at the studied doses.
There is currently no recommendation concerning the safety of leucine administration in patients, due to the lack of dose-ranging studies.
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