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An almost complete lack of developmental data in literature precludes comparison of guppies with other species.
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Although the NGP of the wing patterns was rigorously identified by a comparative morphological procedure, such determinations of homology remain hypothetical because of the lack of developmental genetic data.
Because of the potential for both industrial and consumer exposure to boron-containing compounds, and the lack of developmental toxicity data, the National Toxicology Program evaluated the potential for boric acid to cause developmental toxicity in pregnant Swiss (CD-1) mice, Sprague-Dawley rats (n = 26-28/group 26-28/groupeandNew Zealand(n = 18-23/grabbits
D-cbl mutants display overgrowth and lack of developmental apoptosis.
Incomplete penetrance can be viewed as a lack of developmental canalization.
Given the widespread use and exposure to pesticides, the general lack of data on developmental neurotoxicity is a serious impediment.
For other substances, given their widespread use and the unique vulnerability of the developing brain, the general lack of data on developmental neurotoxicity calls for investment in targeted research.
This aPAD is based on a NOAEL of cerebellum Purkinje cell migration in rat embryos after maternal exposure to 5 mg ETU/kg/day (Khera 1973) and includes a total uncertainty factor of 1,000: 100× for inter- and intraspecies variation, 10× for lack of data on developmental neurotoxicity studies.
The lack of comprehensive data on developmental changes in CSF volume and distribution impairs our understanding of CSF contribution to brain development, and limits the interpretation of blood-CSF permeability data.
The current lack of comprehensive data on developmental changes in CSF spaces still impairs our understanding of CSF contribution to brain development, and limits the interpretation of blood-CSF permeability data.
This pons-dominated conception is now thought to need drastic corrections, due to its lack of a consistent fundament in developmental data (Puelles et al. 2007, 2012b; Watson and Paxinos 2010; Watson et al. 2010; Martínez et al. 2012; Watson 2012).
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