However, the lack of deficits in fear recognition or affective modulation in female subjects with CD is problematic for this position because amygdala lesions are associated with impairments in these processes (68 70).
Though our prediction was that damage to the LMN, and presumably, the ensuing disruption of the head direction cell circuit, would yield deficits in orientation relative to a landmark, the lack of a deficit is consistent with previous studies.
Thus, the current study was designed (1) to replicate previous work showing a lack of schizophrenia deficit in primary somatosensory cortex (SI) gating, and (2) to investigate a possible deficit in secondary somatosensory cortex (SII) gating.
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The lack of a deficit reported here is consistent with the observation that mice lacking NMDA receptor 1 specifically in DG granule neurons can acquire contextual fear conditioning in simple but not in complex conditions [53].
Indeed, the complete lack of any deficit on the object-identity task in Experiment 3 fits well with this assertion.
Therefore the lack of a deficit in the branching, dual-task and delay conditions of the task cannot easily be explained by the fact that these were an atypical high functioning group.
The total distance traveled by WT and KO mice were also very similar underscoring the lack of locomotion deficits in αB-crystallin/HspB2 knockout mice at this age.
According to the view that the ideal ASD model should reproduce all core symptoms and some secondary ones [23], the Fmr1-KO should therefore be of limited validity only, especially in view of the lack of communication deficits that are reported here for the first time.
